Two of Mitchells seven novels has been shortlisted for the Man Booker-price. His authorship startet in 1999 with Ghostwritten. His book Cloud Atlas was adapted for the movies with Tom Hanks as the starring role.

Fredric Jameson described his novel like this: «defined by its relation to future fully as much as to past.»

His newest novel Slade House is on Top 10 in Publishers Weekly.